Champions Manchester City will start the new campaign away at West Ham, while United take on Chelsea and Liverpool kick things off against Norwich
Liverpool will kick off the new Premier League season at home to Norwich on August 9, with champions Manchester City travelling to West Ham and Manchester United playing host to Chelsea on the opening weekend.
Elsewhere, Arsenal will take in a trip to Newcastle on the first Sunday of the new season, while arch-rivals Tottenham take on top-flight new boys Aston Villa 24 hours earlier.
Sheffield United start life back in the big time away at Bournemouth on August 10, with Burnley hosting Southampton, Everton going to Crystal Palace, Leicester taking on Wolves and Watford welcoming Brighton to Vicarage Road.
The big games will come thick and fast from that point.
City’s first home game of the campaign will see them welcome Tottenham to the Etihad Stadium, while Arsenal are due at Anfield in the third round of fixtures.
The first north London derby, which will be staged at Emirates Stadium, is pencilled in for August 31, with a return date taking place on April 25.
City and United will not lock horns until December 7, at the Etihad, with a meeting between two old adversaries at Old Trafford due to be held around March 7.
A Merseyside derby at Anfield will take centre stage on December 4 and at Goodison Park on March 14.
Crystal Palace will rekindle old rivalries with Brighton at Selhurst Park on December 14, before heading to the south coast on February 29.
Aston Villa, who are back in the Premier League after a three-year absence, will face West Midlands foes Wolves at Molineux on November 9 and on home soil on April 4.
Chelsea take on Liverpool on September 21, while Manchester United face Arsenal at Old Trafford a week later.
The Red Devils will then play host to Jurgen Klopp’s Champions League winners on the weekend of October 19, before the following round of games takes Spurs to Anfield.
Liverpool face City on November 9 and Pep Guardiola’s title holders have a tough test at home to Chelsea in the same month.
Spurs pay a visit to United in early December, before then playing host to London neighbours Chelsea in the final group of games before Christmas.
The festive fixture list will see matches moved for television coverage, but the contests around Boxing Day will include Manchester United entertaining Newcastle, City going to Wolves, Liverpool taking in a trip to Leicester, Chelsea playing host to Southampton and Arsenal travelling to Bournemouth.
New Year’s Day could also deliver a feast of entertainment, with United due at the Emirates.
Elsewhere, Liverpool will take on Sheffield United, City clash with Everton, Chelsea go to Brighton and Spurs to Southampton.
Klopp’s men will then have back-to-back outings against Tottenham and Manchester United in January, while Chelsea welcome Arsenal to Stamford Bridge.
Tottenham entertain City on February 1 and the Red Devils visit the Blues of west London a week later.
City versus Arsenal is another contest scheduled for the leap year date of February 29.
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Mid-March will take Manchester United to the Tottenham Hotspur Stadium and City to Stamford Bridge.
Liverpool’s only top-flight defeat of 2018-19 came at the Etihad Stadium, and they will be back there in early April.
May opens with Arsenal entertaining the European champions and a week later takes Chelsea to the red half of Merseyside.
It could be that the title, top-four places and relegation spots are all on the line heading into the final weekend.
Liverpool will be at Newcastle on May 17, Manchester United at Leicester, Spurs at Palace and Sheffield United at Southampton.
Arsenal will play host to Watford, Manchester City will entertain Norwich, Chelsea take on Wolves, Burnley face Brighton, Everton meet Bournemouth and West Ham tackle Aston Villa.